Grieco C, Silipo C, Vittoria A
Farmaco Sci. 1976 Aug;31(8):607-26.
The basic features of the Free-Wilson method for assigning additivity constants to structural features of related compounds is described. The method is presented in considerable operational detail with special emphasis on its development. An original example is discussed. Showing that the substituent constants can be related to more fundamental physico-chemical substituent parameters such as the hydrophobic constants pi.
描述了为相关化合物的结构特征分配加和常数的自由威尔逊方法的基本特征。该方法以相当详细的操作细节呈现，特别强调了其发展过程。讨论了一个原始示例，表明取代基常数可以与更基本的物理化学取代基参数如疏水常数π相关。
