[鸟分枝杆菌感染中使用利福布汀++引起的关节炎]
[Arthritis caused by use of rifabutine++ in Mycobacterium avium infection].
作者信息
van Denderen J C, Mensen E A, Vints A M
机构信息
Jan van Breemen Instituut, Amsterdam.
出版信息
Ned Tijdschr Geneeskd. 1997 Oct 18;141(42):2028-30.
PMID:9550756
Abstract
A 60-year-old HIV-seronegative man with a Mycobacterium avium pulmonary infection was treated with rifabutin, ethambutol and clarithromycin. He developed a serious arthritis which disappeared after interruption of the medication and recurred after resumption. The arthritis was attributed to the use of rifabutin. This adverse effect is more frequent with higher doses and in combination with the use of macrolide antibiotics.
摘要
一名60岁的HIV血清阴性男性，患有鸟分枝杆菌肺部感染，接受了利福布汀、乙胺丁醇和克拉霉素治疗。他出现了严重的关节炎，在停药后消失，恢复用药后复发。这种关节炎被认为是由利福布汀的使用所致。这种不良反应在高剂量使用以及与大环内酯类抗生素联用时更为常见。
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