不同抗生素对家兔肠道中霍乱弧菌O1和O139定植的抑制作用评估。

Evaluation of different antibiotics in inhibiting colonization of Vibrio cholerae O1 and O139 in the rabbit intestine.

作者信息

Chakrabarti M K, Bhattacharya M K, Bhattacharya J, Bhattacharya S K, Mahalanabis D

机构信息

National Institute of Cholera and Enteric Diseases, Calcutta, India.

出版信息

Chemotherapy. 1998 Mar-Apr;44(2):108-11. doi: 10.1159/000007101.

DOI:10.1159/000007101

PMID:9551241

Abstract

The effects of furazolidone, erythromycin and azithromycin in inhibiting colonisation of Vibrio cholerae O1 and O139 in the rabbit intestine were tested. Both V. cholerae O1 and O139 highly colonised the gut in control rabbits. The colonisation of furazolidone-resistant strains in the rabbit intestine was prevented effectively by both erythromycin and azithromycin. In furazolidone-sensitive strains, the efficacies of erythromycin and azithromycin were very much comparable to furazolidone. These results suggested that azithromycin may be subjected to clinical trial in comparison to furazolidone and erythromycin for the treatment of cholera due to O1 and O139 infection in children.

摘要

测试了呋喃唑酮、红霉素和阿奇霉素对兔肠道中霍乱弧菌O1和O139定植的抑制作用。在对照兔中，霍乱弧菌O1和O139均能在肠道中高度定植。红霉素和阿奇霉素均能有效阻止耐呋喃唑酮菌株在兔肠道中的定植。在呋喃唑酮敏感菌株中，红霉素和阿奇霉素的疗效与呋喃唑酮非常相似。这些结果表明，与呋喃唑酮和红霉素相比，阿奇霉素可能值得进行临床试验，用于治疗儿童由O1和O139感染引起的霍乱。