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[使用数学模型研究气体进入人体过程的动力学]

[Dynamics of the process of gas transport into the body using a mathematical model].

作者信息

Kolchinskaia A Z, Misiura A G, Pshenichnyĭ B N, Onopchuk Iu N, Marchenko D I

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1976 Jul;62(7):1047-55.

PMID:955147
Abstract

Dynamics of mass-transport of oxygen, carbon dioxide, and inert gases in lungs, blood, and tissues, as well as gas transport through alveolar capillary and erythrocyte membranes at rest and during exercise under normal and increased ambient pressures, were studied on a mathematical model. The model consists of 34 differential and 58 algebraic equations and makes it possible to estimate the dynamics of changes of over 90 parameters. The effect of various factors: duration of the respiratory cycle, tidal volume, airways resistance, the surface of diffusion, the resistance of alveolar-capillary wall, erythrocyte membrane, ventilation-perfusion relations, pulmonary blood shunts, blood supply to the tissues, Haldane and Verigo-Bohr effect, buffer capacity of the blood, and others) on the mass-transport of gases were quantitatively estimated.

摘要

在一个数学模型上研究了氧气、二氧化碳和惰性气体在肺、血液和组织中的质量传输动力学,以及在正常和升高的环境压力下,静息和运动期间气体通过肺泡毛细血管和红细胞膜的传输情况。该模型由34个微分方程和58个代数方程组成,能够估计90多个参数的变化动态。定量评估了各种因素(呼吸周期持续时间、潮气量、气道阻力、扩散表面积、肺泡-毛细血管壁阻力、红细胞膜阻力、通气-灌注关系、肺内血液分流、组织血液供应、哈代效应和韦里戈-玻尔效应、血液缓冲能力等)对气体质量传输的影响。

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