Kulik A M, Kondrat'eva L N, Tarakanov I A
Fiziol Zh SSSR Im I M Sechenova. 1976 Jul;62(7):990-6.
The functional state of the respiratory center and the mechanism of increase in pulmonary ventilation before and after inhibition of activity of carbonic anhydrase by diamox were studied in anesthetized cats. During the inhibition, activity of bulbar inspiratory neurons functionally connected with motoneurons of the diaphragm was markedly reduced and that of the neurons connected with motoneurons of intercostal muscles was sharply increased. A steady thoracic respiration occurred. The aferents from the carotid sinus nerve and vagus nerve did not affect the steady thoracic respiration. Increased efferent influence upon the intercostal muscles led to forced thoracic respiration which ensured a high pulmonary ventilation during the whole period of action of the diamox.
在麻醉猫身上研究了碳酸酐酶活性被乙酰唑胺抑制前后呼吸中枢的功能状态以及肺通气增加的机制。在抑制过程中，与膈肌运动神经元功能相连的延髓吸气神经元活性显著降低，而与肋间肌运动神经元相连的神经元活性急剧增加。出现了稳定的胸式呼吸。来自颈动脉窦神经和迷走神经的传入神经不影响稳定的胸式呼吸。对肋间肌传出影响的增加导致强制性胸式呼吸，这确保了在乙酰唑胺作用的整个期间有高肺通气。
