Martín-Castellanos C, Moreno S
Departamento de Microbiología y Genética, CSIC/Universidad de Salamanca, Spain.
Prog Cell Cycle Res. 1996;2:29-35. doi: 10.1007/978-1-4615-5873-6_3.
Recently it has been found that B-type cyclins in fission yeast regulate the activation of the cdc2 kinase to promote the onset of both DNA replication and mitosis. cig2 is the major G1 cyclin while cdc13 is the principal mitotic cyclin. cdc13 also has an additional function in G2 phase, preventing more than one round of DNA replication per cell cycle. In opposition to these cyclins the rum1 inhibitor, a protein present exclusively in G1, prevents premature activation of the cdc2/cig2 and the cdc2/cdc13 complexes until cells have reached the critical cell size required to pass Start and initiate a new cell cycle.
最近发现，裂殖酵母中的B型细胞周期蛋白调节cdc2激酶的激活，以促进DNA复制和有丝分裂的开始。cig2是主要的G1期细胞周期蛋白，而cdc13是主要的有丝分裂细胞周期蛋白。cdc13在G2期还具有额外功能，可防止每个细胞周期进行一轮以上的DNA复制。与这些细胞周期蛋白相反，rum1抑制剂是一种仅存在于G1期的蛋白质，可防止cdc2/cig2和cdc2/cdc13复合物过早激活，直到细胞达到通过起始点并启动新细胞周期所需的临界细胞大小。
