Chun K T, Mathias N, Goebl M G
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis 46202-5122, USA.
Prog Cell Cycle Res. 1996;2:115-27. doi: 10.1007/978-1-4615-5873-6_12.
Genetic and biochemical data indicate that ubiquitin-mediated proteolysis is involved in the regulated turnover of proteins required for controlling cell cycle progression. In general, mutations in some genes that encode proteins involved in the ubiquitin pathway cause cell cycle defects and affect the turnover of cell cycle regulatory proteins. Furthermore, some cell cycle regulatory proteins are short-lived, ubiquitinated, and degraded by the ubiquitin pathway. This review will examine how the ubiquitin pathway plays a role in regulating progression from the G1 to the S phase of the cell cycle, as well as the G2 to M phase transition.
遗传和生化数据表明，泛素介导的蛋白水解参与了控制细胞周期进程所需蛋白质的调节性周转。一般来说，一些编码参与泛素途径蛋白质的基因突变会导致细胞周期缺陷，并影响细胞周期调节蛋白的周转。此外，一些细胞周期调节蛋白寿命较短，会被泛素化，并通过泛素途径降解。本综述将探讨泛素途径如何在调节细胞周期从G1期到S期的进程以及从G2期到M期的转变中发挥作用。
