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Multiple roles of the proliferating cell nuclear antigen: DNA replication, repair and cell cycle control.

作者信息

Prosperi E

机构信息

Dipartimento di Biologia Animale, Università di Pavia, Italy.

出版信息

Prog Cell Cycle Res. 1997;3:193-210. doi: 10.1007/978-1-4615-5371-7_15.

DOI:10.1007/978-1-4615-5371-7_15
PMID:9552415
Abstract

The proliferating cell nuclear antigen (PCNA), the auxiliary protein of DNA polymerase delta and epsilon, is involved in DNA replication and repair. This protein forms a homotrimeric structure which, encircling DNA, loads the polymerase on the DNA template. A role for PCNA in the cell cycle control is recognised on the basis of the interaction with cyclins, cyclin-dependent kinases (cdks) and the cdk-inhibitor p21 waf1/cip1/sdi1 protein. Association with the growth-arrest and DNA-damage inducible proteins gadd45 and MyD118, further demonstrates the role of PCNA as a component of the cell cycle control apparatus.

摘要

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