Myt1：一种Wee1型激酶，可使Cdc2的苏氨酸14位点发生磷酸化。

Myt1: a Wee1-type kinase that phosphorylates Cdc2 on residue Thr14.

作者信息

Fattaey A, Booher R N

机构信息

Onyx Pharmaceuticals, Richmond, CA 94806, USA.

出版信息

Prog Cell Cycle Res. 1997;3:233-40. doi: 10.1007/978-1-4615-5371-7_18.

DOI:10.1007/978-1-4615-5371-7_18

PMID:9552418

Abstract

Most somatic cell division cycles contain a gap period (G2 phase) between the completion of DNA synthesis and the initiation of mitosis. This delay of mitotic entry is controlled, at least in part, by the repression of Cdc2 kinase activity by the phosphorylation of two conserved residues (Thr14 and Tyr15) within the ATP-binding pocket of the Cdc2 catalytic subunit. The kinases responsible for these two phosphorylation events include the Myt1 and Wee1 kinases, which phosphorylate Cdc2 on Thr14 and Tyr15, respectively. In this discussion, we summarise our current knowledge of the Myt1 kinase and its regulation of Cdc2 kinase activity during the G2-to -M phase transition.

摘要

大多数体细胞分裂周期在DNA合成完成和有丝分裂开始之间包含一个间隙期（G2期）。有丝分裂进入的这种延迟至少部分是由Cdc2催化亚基ATP结合口袋内两个保守残基（Thr14和Tyr15）的磷酸化对Cdc2激酶活性的抑制所控制。负责这两个磷酸化事件的激酶包括Myt1激酶和Wee1激酶，它们分别在Thr14和Tyr15上使Cdc2磷酸化。在本讨论中，我们总结了我们目前对Myt1激酶及其在G2期到M期转变过程中对Cdc2激酶活性调控的认识。