联合使用肝素/阿司匹林和免疫球蛋白G治疗体外受精的抗甲状腺抗体患者。
The use of combined heparin/aspirin and immunoglobulin G therapy in the treatment of in vitro fertilization patients with antithyroid antibodies.
作者信息
Sher G, Maassarani G, Zouves C, Feinman M, Sohn S, Matzner W, Chong P, Ching W
机构信息
Pacific Fertility Medical Centers of California, Los Angeles 90024, USA.
出版信息
Am J Reprod Immunol. 1998 Apr;39(4):223-5. doi: 10.1111/j.1600-0897.1998.tb00357.x.
PROBLEM
To compare the effect of heparin/aspirin therapy alone vs. heparin/aspirin in combination with intravenous immuno-globulin (IVIg) immunotherapy on in vitro fertilization (IVF) outcome of patients who test positive for antithyroid antibodies (ATAs).
METHOD OF STUDY
Eighty-two women younger than 40 years of age whose infertility was related exclusively to female causes were evaluated. All tested positive for organ-specific antithyroid antibodies (antimicrosomal and/or antithyroglobulin antibodies), but negative for antiphospholipid antibodies. Thirty-seven of these women (group A) received H/A alone, whereas 45 (group B) received heparin/aspirin in combination with IVIg.
RESULTS
Ten (27%) of women in group A and 23 (51%) of women in group B achieved live births after completion of a single IVF/embryo transfer cycle (P = 0.027).
CONCLUSION
We conclude that IVIg therapy significantly improves IVF success rates in ATA+ women.
问题
比较单独使用肝素/阿司匹林疗法与肝素/阿司匹林联合静脉注射免疫球蛋白（IVIg）免疫疗法对甲状腺自身抗体（ATA）检测呈阳性的患者体外受精（IVF）结局的影响。
研究方法
评估了82名年龄小于40岁、不孕仅由女性因素引起的女性。所有患者器官特异性甲状腺自身抗体（抗微粒体和/或抗甲状腺球蛋白抗体）检测均呈阳性，但抗磷脂抗体检测呈阴性。其中37名女性（A组）仅接受肝素/阿司匹林治疗，而45名女性（B组）接受肝素/阿司匹林联合IVIg治疗。
结果
A组10名（27%）女性和B组23名（51%）女性在完成单个IVF/胚胎移植周期后成功分娩（P = 0.027）。
结论
我们得出结论，IVIg疗法可显著提高ATA阳性女性的IVF成功率。
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