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[再生大鼠肝细胞S期和G2期染色体放射敏感性的比较]

[Comparison of the radiosensitivity of chromosomes during the S and G2 periods in regenerating rat liver cells].

作者信息

Polishchuk A M, Aksenovich T I, Mamaeva O A

出版信息

Genetika. 1976;12(4):35-40.

PMID:955412
Abstract

Radiosensitivity of chromosomes at S and G2 periods was studied by means of autoradiography technique in cells or regenerating liver of rats treated with X-rays at the doses of 150 and 300 r. The experiments were made so that the interval between irradiation and mitosis in S and G2 cells was equal. The results have shown that under the experimental conditions there are significant differences in the yield of chromosome aberrations between the labelled and intact cells. This withnesses for the existence of differences in radiosensitivity of chromosomes at different periods of mitotic cycle.

摘要

采用放射自显影技术,研究了用150伦琴和300伦琴剂量的X射线照射大鼠再生肝或细胞后,处于S期和G2期染色体的放射敏感性。实验设计使得S期和G2期细胞照射与有丝分裂之间的间隔相等。结果表明,在实验条件下,标记细胞与完整细胞之间染色体畸变率存在显著差异。这证明有丝分裂周期不同时期染色体的放射敏感性存在差异。

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