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[不同细胞周期阶段再生大鼠肝细胞经X射线照射诱导的染色体畸变率]

[Yield of chromosome aberrations induced by x-irradiation in regenerating rat liver cells at different periods of the generation cycle].

作者信息

Gil'iano N Ia, Malinovskiĭ O V

出版信息

Tsitologiia. 1977 Mar;19(3):367-72.

PMID:883033
Abstract

The yield of cells with chromosome aberrations was studied using 630 rad X-irradiated liver cells of intact and hepatectomied rats, hepatectomy being performed 2-24 hours before irradiation. The radiosensitivity was variable throughout the cell cycle. The kinetic curve of radiosensitivity changes shows two ranges of radioresistance: in the early period G1 and in the middle period S, as well as the range of a relatively high sensitivity in the middle of period G1. The increase in radiosensitivity is also characteristic of the G0-G1 transition (4 hours after the stimulation).

摘要

利用630拉德X射线照射完整大鼠和肝切除大鼠的肝细胞来研究染色体畸变细胞的产率,肝切除在照射前2 - 24小时进行。在整个细胞周期中,放射敏感性是可变的。放射敏感性变化的动力学曲线显示出两个放射抗性范围:在G1期早期和S期中期,以及在G1期中期有一个相对高敏感性范围。放射敏感性的增加也是G0 - G1转换(刺激后4小时)的特征。

相似文献

1
[Yield of chromosome aberrations induced by x-irradiation in regenerating rat liver cells at different periods of the generation cycle].[不同细胞周期阶段再生大鼠肝细胞经X射线照射诱导的染色体畸变率]
Tsitologiia. 1977 Mar;19(3):367-72.
2
[Comparison of the radiosensitivity of chromosomes during the S and G2 periods in regenerating rat liver cells].[再生大鼠肝细胞S期和G2期染色体放射敏感性的比较]
Genetika. 1976;12(4):35-40.
3
[Change in the radiosensitivity of chromosomes during the S-period in cells of regenerating rat liver].[再生大鼠肝细胞S期染色体放射敏感性的变化]
Genetika. 1977;13(7):1194-1201.
4
[Mitotic activity and chromosome aberrations in regenerating rat liver following x-ray irradiation].
Biull Eksp Biol Med. 1981 Mar;91(3):359-61.
5
[DNA synthesis and mitotic activity in cells of regenerating rat liver following x-irradiation in stages GO and Gl].[处于G0期和G1期的大鼠肝脏细胞经X射线分期照射后再生过程中的DNA合成与有丝分裂活性]
Tsitologiia. 1976 Oct;18(10):1284-8.
6
[Polyploidization of rat hepatocytes induced by x-ray radiation at different periods of the cell cycle].[不同细胞周期阶段X射线辐射诱导大鼠肝细胞多倍体化]
Radiobiologiia. 1987 May-Jun;27(3):375-7.
7
[Effect of x-irradiation on cell nucleus size and DNA content in the regenerating rat liver].[X射线照射对再生大鼠肝脏细胞核大小和DNA含量的影响]
Biull Eksp Biol Med. 1981 Apr;91(4):490-2.
8
Mitotic delay and chromosomal aberrations induced by X rays in synchronized Chinese hamster cells in vitro.X射线在体外同步化的中国仓鼠细胞中诱导的有丝分裂延迟和染色体畸变。
J Natl Cancer Inst. 1967 Oct;39(4):619-32.
9
Repair and latent injury in rat liver after x-irradiation.大鼠肝脏X线照射后的修复与潜在损伤
Radiology. 1972 Oct;105(1):195-8. doi: 10.1148/105.1.195.
10
[Action of x-ray irradiation on the nuclear envelope of rat liver cells].[X射线照射对大鼠肝细胞细胞核膜的作用]
Tsitologiia. 1979 Jul;21(7):768-74.