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[不同细胞周期阶段再生大鼠肝细胞经X射线照射诱导的染色体畸变率]

[Yield of chromosome aberrations induced by x-irradiation in regenerating rat liver cells at different periods of the generation cycle].

作者信息

Gil'iano N Ia, Malinovskiĭ O V

出版信息

Tsitologiia. 1977 Mar;19(3):367-72.

PMID:883033
Abstract

The yield of cells with chromosome aberrations was studied using 630 rad X-irradiated liver cells of intact and hepatectomied rats, hepatectomy being performed 2-24 hours before irradiation. The radiosensitivity was variable throughout the cell cycle. The kinetic curve of radiosensitivity changes shows two ranges of radioresistance: in the early period G1 and in the middle period S, as well as the range of a relatively high sensitivity in the middle of period G1. The increase in radiosensitivity is also characteristic of the G0-G1 transition (4 hours after the stimulation).

摘要

利用630拉德X射线照射完整大鼠和肝切除大鼠的肝细胞来研究染色体畸变细胞的产率,肝切除在照射前2 - 24小时进行。在整个细胞周期中,放射敏感性是可变的。放射敏感性变化的动力学曲线显示出两个放射抗性范围:在G1期早期和S期中期,以及在G1期中期有一个相对高敏感性范围。放射敏感性的增加也是G0 - G1转换(刺激后4小时)的特征。

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