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新墨西哥州老年人肌肉减少症的流行病学

Epidemiology of sarcopenia among the elderly in New Mexico.

作者信息

Baumgartner R N, Koehler K M, Gallagher D, Romero L, Heymsfield S B, Ross R R, Garry P J, Lindeman R D

机构信息

Clinical Nutrition Program, Center for Population Health, University of New Mexico School of Medicine, Albuquerque 87131, USA.

出版信息

Am J Epidemiol. 1998 Apr 15;147(8):755-63. doi: 10.1093/oxfordjournals.aje.a009520.

Abstract

Muscle mass decreases with age, leading to "sarcopenia," or low relative muscle mass, in elderly people. Sarcopenia is believed to be associated with metabolic, physiologic, and functional impairments and disability. Methods of estimating the prevalence of sarcopenia and its associated risks in elderly populations are lacking. Data from a population-based survey of 883 elderly Hispanic and non-Hispanic white men and women living in New Mexico (the New Mexico Elder Health Survey, 1993-1995) were analyzed to develop a method for estimating the prevalence of sarcopenia. An anthropometric equation for predicting appendicular skeletal muscle mass was developed from a random subsample (n = 199) of participants and was extended to the total sample. Sarcopenia was defined as appendicular skeletal muscle mass (kg)/height2 (m2) being less than two standard deviations below the mean of a young reference group. Prevalences increased from 13-24% in persons under 70 years of age to >50% in persons over 80 years of age, and were slightly greater in Hispanics than in non-Hispanic whites. Sarcopenia was significantly associated with self-reported physical disability in both men and women, independent of ethnicity, age, morbidity, obesity, income, and health behaviors. This study provides some of the first estimates of the extent of the public health problem posed by sarcopenia.

摘要

肌肉量会随着年龄增长而减少,导致老年人出现“肌肉减少症”,即相对肌肉量较低的情况。肌肉减少症被认为与代谢、生理和功能障碍以及残疾有关。目前缺乏估算老年人群中肌肉减少症患病率及其相关风险的方法。对来自新墨西哥州883名西班牙裔和非西班牙裔白人老年男性和女性的基于人群的调查数据(1993 - 1995年新墨西哥州老年人健康调查)进行了分析,以开发一种估算肌肉减少症患病率的方法。从参与者的随机子样本(n = 199)中得出了一个预测四肢骨骼肌量的人体测量方程,并将其扩展到整个样本。肌肉减少症的定义为四肢骨骼肌量(千克)/身高²(平方米)低于年轻参照组均值两个标准差。患病率从70岁以下人群的13 - 24%增加到80岁以上人群的>50%,西班牙裔人群的患病率略高于非西班牙裔白人。无论男性还是女性,肌肉减少症都与自我报告的身体残疾显著相关,且不受种族、年龄、发病率、肥胖、收入和健康行为的影响。这项研究首次对肌肉减少症所带来的公共卫生问题的严重程度进行了一些估算。

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