Harthoorn-Lasthuizen E J, Lindemans J, Langenhuijsen M M
Laboratory of Hematology, Bosch Medicentrum, NL 's-Hertogenbosch, The Netherlands.
Clin Chem. 1998 Apr;44(4):800-4.
Erythrocyte zinc protoporphyrin (ZPP) was measured in 102 women blood donors to evaluate its usefulness in screening for evolving iron deficiency anemia, a reason for the deferral of donors. The results were compared with serum ferritin determinations. Five women were deferred before their first donation and eight women were deferred after one or two donations. Women with increased ZPP values all had low serum ferritin concentrations, indicating iron-deficient erythropoiesis that was caused by iron depletion. The positive predictive value of an increased ZPP in predicting deferral of the donor after one or two donations was 75%, whereas a serum ferritin concentration < or = 12 microg/L predicted deferral in 26% of the donors. The results indicate that the ZPP test can be recommended as a feasible and inexpensive predonation test to determine a subset of donors with iron-deficient erythropoiesis at risk of developing iron deficiency anemia.
对102名女性献血者进行了红细胞锌原卟啉（ZPP）检测，以评估其在筛查隐匿性缺铁性贫血（这是献血者延期献血的一个原因）方面的效用。将结果与血清铁蛋白测定结果进行了比较。5名女性在首次献血前被延期，8名女性在一次或两次献血后被延期。ZPP值升高的女性血清铁蛋白浓度均较低，表明存在因铁耗竭导致的缺铁性红细胞生成。ZPP升高对预测一次或两次献血后献血者延期的阳性预测值为75%，而血清铁蛋白浓度≤12μg/L可预测26%的献血者延期。结果表明，ZPP检测可作为一种可行且经济的献血前检测方法，用于确定一部分有缺铁性红细胞生成风险、可能发展为缺铁性贫血的献血者。
