Hartenstein R
Fortschr Med. 1976 May 6;94(13):765-70.
The results of intermittent high-dose-therapy, especially with Doxorubicin and Amethopterin, are encouraging, particularly, against those malignant tumors which were difficult to influence until now. The damage to normal tissue and especially the therapy-limiting cumulative toxicity, seem to be lower if compared with the continuous low-dose-treatment because of the possibility for complete recovery of normal tissue during therapy-free intervals. Correlations between tumor, normal tissue and cytotoxic agent are discussed on the basis of cellkinetic findings to contribute to a better understanding of the way of action of a high-dose-therapy.
间歇性高剂量疗法的结果，尤其是使用阿霉素和氨甲蝶呤的疗法，令人鼓舞，特别是对于那些迄今为止难以治疗的恶性肿瘤。与持续低剂量治疗相比，对正常组织的损害，尤其是限制治疗的累积毒性，似乎更低，因为在无治疗间隔期正常组织有可能完全恢复。基于细胞动力学研究结果讨论了肿瘤、正常组织和细胞毒性药物之间的相关性，以有助于更好地理解高剂量疗法的作用方式。
