Mims R B, Lopez R J, Finck U A, Bethune J E
Horm Metab Res. 1976 Jul;8(4):295-8. doi: 10.1055/s-0028-1093639.
We have observed an apparent hypoglobulinemia in 17 of 35 patients (48.6%) with acromegaly. This unexpected finding was persistent and reproducible up to six years for five acromegalic patients, and more than one year for nine other patients. Serum globulin was analyzed by three different methods, and the deficiency was most noticeable in the alpha globulin fraction (alpha1 greater than alpha2). When hypoglobulinemia occurred in control hospital in-patients (11%) it was associated with chronic or severe illnesses, and limited nutritional intake, but similar medical problems were absent in the acromegalic patients. There was no correlation of the hypoglobulinemia in the 35 acromegalic patients to their growth hormone (GH) concentration (r = 0.07), ages, sex, treatment status, or to the seriousness or duration of the acromegaly. The pathophysiology of the apparent hypoglobulinemia in acromegaly is unknown, but may be related to transport and/or disposal of excess growth hormone, or a defect in protein synthesis.
我们在35例肢端肥大症患者中的17例（48.6%）观察到明显的球蛋白血症。这一意外发现对于5例肢端肥大症患者持续了6年且可重复出现，对于另外9例患者持续了1年多。采用三种不同方法分析血清球蛋白，发现缺乏在α球蛋白部分最为明显（α1大于α2）。对照医院住院患者出现球蛋白血症（11%）时，与慢性或严重疾病以及营养摄入受限有关，但肢端肥大症患者不存在类似的医学问题。35例肢端肥大症患者的球蛋白血症与他们的生长激素（GH）浓度（r = 0.07）、年龄、性别、治疗状态，或与肢端肥大症的严重程度或病程均无相关性。肢端肥大症中明显的球蛋白血症的病理生理学尚不清楚，但可能与过量生长激素的转运和/或清除，或蛋白质合成缺陷有关。
