Federspil G, Vettor R, Bossi A, Sicolo N
J Endocrinol Invest. 1979 Apr-Jun;2(2):217-9. doi: 10.1007/BF03349317.
Although it is well known that growth hormone may influence protein metabolism, few investigations have been undertaken on serum protein levels in acromegaly; recently hypoglobulinemia has been observed in this endocrine disorder. In 28 acromegalic patients and 56 control subjects sera have been analyzed for total protein determination and for electrophoretic protein separation. The results have shown that in acromegalic there is a slight but statistically highly significant decrease of serum total protein (mean +/- SE 6.66 +/- 0.07 g/100 ml vs 7.10 +/- 0.07 g/100 ml), albumin, alpha 1 and alpha 2-globulins. Since growth hormone stimulates protein synthesis, the pathophysiological significance of hypoproteinemia of acromegaly is at present obscure.
虽然众所周知生长激素可能影响蛋白质代谢，但针对肢端肥大症患者血清蛋白水平的研究却很少；最近在这种内分泌疾病中观察到了低球蛋白血症。对28例肢端肥大症患者和56例对照者的血清进行了总蛋白测定和蛋白质电泳分离分析。结果显示，肢端肥大症患者血清总蛋白（均值±标准误6.66±0.07g/100ml，对照者为7.10±0.07g/100ml）、白蛋白、α1和α2球蛋白均有轻微但在统计学上具有高度显著性的下降。由于生长激素刺激蛋白质合成，目前肢端肥大症低蛋白血症的病理生理意义尚不清楚。
