Wilkinson P C, Komai-Koma M, Newman I
Immunology Department, University of Glasgow (Western Infirmary), UK.
Autoimmunity. 1997;26(1):55-72. doi: 10.3109/08916939709009550.
The behaviour of locomotor T and B lymphocytes and the chemoattractants to which they respond in vitro are reviewed. Following activation, T cells respond by locomotion and chemotaxis to cytokine attractants including IL-15 and IL-2 and several chemokines. In activated B cells chemotaxis may be signalled through the antigen receptor. Conversely resting lymphocytes respond poorly to the above signals though their locomotion is activated by contact with high endothelial venular cells. These differences in locomotion between resting and activated lymphocytes, together with differences in adhesion, may explain why activated lymphocytes migrate preferentially into inflammatory sites while resting cells recirculate.
本文综述了运动性T和B淋巴细胞的行为及其在体外所响应的趋化因子。激活后，T细胞通过运动和趋化作用对包括IL-15、IL-2和几种趋化因子在内的细胞因子趋化剂作出反应。在活化的B细胞中，趋化作用可能通过抗原受体发出信号。相反，静止淋巴细胞对上述信号反应较差，尽管它们的运动通过与高内皮小静脉细胞接触而被激活。静止淋巴细胞和活化淋巴细胞在运动方面的这些差异，以及黏附方面的差异，可能解释了为什么活化淋巴细胞优先迁移到炎症部位，而静止细胞则进行再循环。
