封闭敷料和高压氧对皮瓣存活及缺血性伤口愈合的影响。

The influence of occlusive dressing and hyperbaric oxygen on flap survival and the healing of ischaemic wounds.

作者信息

Quirinia A, Viidik A

机构信息

Department of Connective Tissue Biology, University of Aarhus, Denmark.

出版信息

Scand J Plast Reconstr Surg Hand Surg. 1998 Mar;32(1):1-8. doi: 10.1080/02844319850158895.

DOI:10.1080/02844319850158895

PMID:9556815

Abstract

The effect of dressing with Duoderm (hydrocolloid) and treatment with hyperbaric oxygen was investigated on the healing of ischaemic incisional wounds and on flap survival in rats. After 10 days, Duoderm dressing of ischaemic wounds decreased all strength parameters (loadS, stressS) by 41%-44% and the improvement of ischaemic wound healing by hyperbaric oxygen treatment shown in our previous study was not seen. After removal of Duoderm on day 10 the biomechanical properties had improved but not returned to normal on day 20. In the dressed animals the shrinkage of ischaemic wounds and the extension of necrosis on the ischaemic flaps were reduced. Dressing may be useful clinically in preventing superficial dermal necroses. One must, however, be aware of the impairment of the wound strength of the incisional wounds.

摘要

研究了使用多爱肤（水胶体）敷料以及高压氧治疗对大鼠缺血性切口伤口愈合和皮瓣存活的影响。10天后，缺血性伤口的多爱肤敷料使所有强度参数（负荷S、应力S）降低了41%-44%，且未观察到我们之前研究中显示的高压氧治疗对缺血性伤口愈合的改善作用。在第10天去除多爱肤后，生物力学性能有所改善，但在第20天仍未恢复正常。在使用敷料的动物中，缺血性伤口的收缩以及缺血皮瓣坏死范围的扩大均有所减少。敷料在临床上可能有助于预防表皮坏死。然而，必须注意到其对切口伤口强度的损害。