Quirinia A, Viidik A
Department of Connective Tissue Biology, University of Aarhus, Denmark.
Scand J Plast Reconstr Surg Hand Surg. 1997 Sep;31(3):213-9. doi: 10.3109/02844319709051534.
The influence of diclofenac and indomethacin on the healing of normal (non-ischaemic) incisional wounds, and of ischaemic incisional wounds using a flap model, was studied in 192 rats. Both drugs improved the strength of normal wounds as the energies at maximum load and stress increased by 23% - 33% after 10 days. After 20 days the treated normal wounds were stiffer. In ischaemic wounds neither drug influenced the biomechanical properties after 10 days, which reflects the healing of the deep dermis, but both countered the ischaemia of the superficial skin as the necroses on the skin flaps decreased. After 20 days the drugs decreased some of the strength parameters of ischaemic wounds, indomethacin in particular, which decreased these parameters by about 20% - 35%. In conclusion, in certain doses the drugs improved the healing of normal wounds. The healing of ischaemic wounds was unaffected after 10 days but decreased after 20 days. The drugs may, however, be used for reducing superficial necroses of skin flaps.
在192只大鼠身上研究了双氯芬酸和吲哚美辛对正常（非缺血性）切口伤口愈合的影响，以及使用皮瓣模型对缺血性切口伤口愈合的影响。两种药物均提高了正常伤口的强度，因为在10天后最大负荷和应力下的能量增加了23% - 33%。20天后，经治疗的正常伤口更硬。在缺血性伤口中，10天后两种药物均未影响生物力学性能，这反映了深层真皮的愈合，但随着皮瓣上坏死区域的减少，两种药物均对抗了浅表皮肤的缺血。20天后，药物降低了缺血性伤口的一些强度参数，尤其是吲哚美辛，它使这些参数降低了约20% - 35%。总之，在特定剂量下，这些药物改善了正常伤口的愈合。缺血性伤口在10天后愈合未受影响，但在20天后愈合有所下降。然而，这些药物可用于减少皮瓣的浅表坏死。
