高压氧对皮肤缺血皮瓣伤口和切开伤口愈合不同阶段的影响。

The effect of hyperbaric oxygen on different phases of healing of ischaemic flap wounds and incisional wounds in skin.

作者信息

Quirinia A, Viidik A

机构信息

Department of Connective Tissue Biology, University of Aarhus, Denmark.

出版信息

Br J Plast Surg. 1995 Dec;48(8):583-9. doi: 10.1016/0007-1226(95)90049-7.

DOI:10.1016/0007-1226(95)90049-7

PMID:8548161

Abstract

Several studies have revealed a positive effect of treatment of ischaemic wounds and flaps with hyperbaric oxygen. We studied the effect of 100% oxygen (2.4 ATA) for 90 min daily on different phases of healing ischaemic and normal incisional wounds in rats. Hyperbaric oxygen on day 0-3 significantly increased almost all the force parameters of ischaemic flap wounds by 41-57% after 10 days of healing. On the other hand, when the treatment was continued until day 9 the positive effect on the wound healing was abolished. Furthermore, when hyperbaric oxygen was given on days 4-9 there was a tendency towards a decrease in the biomechanical parameters. Hyperbaric oxygen had no effect on the healing of normal incisional wounds.

摘要

多项研究表明，高压氧治疗对缺血性伤口和皮瓣有积极作用。我们研究了每天用100%氧气（2.4ATA）持续90分钟对大鼠缺血性和正常切口伤口愈合不同阶段的影响。在愈合10天后，第0 - 3天进行高压氧治疗可使缺血皮瓣伤口的几乎所有力学参数显著提高41 - 57%。另一方面，若将治疗持续至第9天，对伤口愈合的积极作用则消失。此外，在第4 - 9天给予高压氧时，生物力学参数有下降趋势。高压氧对正常切口伤口的愈合没有影响。