Hodgson Philip, Jordan Alastair, Sinani Charikleia, Charura Divine
Physiotherapy Department, Tees, Esk and Wear Valleys NHS Foundation Trust, West Park Hospital, Darlington, United Kingdom.
School of Science, Technology and Health, York St John University, York, United Kingdom.
PLoS One. 2024 Dec 16;19(12):e0315345. doi: 10.1371/journal.pone.0315345. eCollection 2024.
Individuals with Parkinson's Disease (PD) often experience not only physical symptoms but also a higher prevalence of psychological issues, including depression, anxiety, schizophrenia, and psychotic symptoms, compared to the general population. The relationship between these physical and psychological symptoms remains poorly understood, particularly in relation to commonly used measures of physical function and a wider variety of psychological symptoms. Investigating this link is essential for optimising patient care. This cohort study is registered with OSF (https://osf.io/c7tvd).
The primary aim of this study is to investigate the association between physical and psychological symptoms in PD. We will focus specifically on measures of physical function such as balance and mobility, assess the similarities between physiotherapist and participant-rated measures, and monitor changes over time.
This cohort study plans to recruit 30 participants with PD, who will be monitored over a 12-month period. Data will be collected at baseline and completion, providing two data points per participant. Selected outcome measures will include physical function (objective measures), non-motor symptoms, participants perceived function, and engagement in physical activity. Correlations between outcomes will be analysed, and multivariate regression modelling may be employed for time-series analysis to evaluate how relationships change over time. Descriptive summaries of all outcomes will be presented in tables.
Ethical approval for this study was obtained on 15th July 2024, with participant recruitment scheduled to begin in October 2024. Data collection is expected to conclude by August 2026, with final results anticipated within six months of study completion.
This study will be the first to monitor this specific set of physical and psychological outcomes over time in individuals with PD. The findings are expected to provide valuable insights into the relationship between these symptoms, informing future research and potentially leading to larger-scale, multi-site studies conducted over extended assessment periods.
与普通人群相比，帕金森病（PD）患者不仅常出现身体症状，还更易出现包括抑郁、焦虑、精神分裂症和精神病性症状在内的心理问题。这些身体和心理症状之间的关系仍未得到充分理解，尤其是在与常用的身体功能测量方法以及更广泛的心理症状方面。研究这种联系对于优化患者护理至关重要。本队列研究已在开放科学框架（OSF，https://osf.io/c7tvd）注册。
本研究的主要目的是调查帕金森病患者身体和心理症状之间的关联。我们将特别关注平衡和活动能力等身体功能测量指标，评估物理治疗师评定指标与患者自评指标之间的相似性，并监测随时间的变化。
本队列研究计划招募30名帕金森病患者，对其进行为期12个月的监测。将在基线和结束时收集数据，每位参与者提供两个数据点。选定的结局指标将包括身体功能（客观指标）、非运动症状、患者感知功能以及身体活动参与情况。将分析各结局指标之间的相关性，可能采用多变量回归模型进行时间序列分析，以评估关系如何随时间变化。所有结局指标的描述性总结将以表格形式呈现。
本研究于2024年7月15日获得伦理批准，计划于2024年10月开始招募参与者。预计数据收集将于2026年8月结束，最终结果预计在研究完成后的六个月内得出。
本研究将是首个长期监测帕金森病患者这一特定身体和心理结局指标集的研究。预计研究结果将为这些症状之间的关系提供有价值的见解，为未来研究提供参考，并可能促使在更长评估期内开展更大规模的多中心研究。
