Cleophas T J
Department of Medicine, Merwede Hospital, Dordrecht, Netherlands.
Neth J Med. 1998 Feb;52(2):82-9. doi: 10.1016/s0300-2977(97)00084-3.
Mental depression and myocardial infarction (MI) are closely related. The current paper reviews pathophysiological mechanisms that could link depression to MI and discusses the pros and cons of different pharmacological and non-pharmacological treatment modalities that could be considered. The selective serotonin reuptake inhibitors lack arrhythmogenic effects, and have a beneficial effect in addition to depression on psychological factors, such as anxiety and mood disturbances, which are not uncommon in post-MI patients. Studies to further determine the impact of depression on the outcome of MI, and the place of different treatment modalities are in progress.
精神抑郁与心肌梗死（MI）密切相关。本文综述了可能将抑郁与心肌梗死联系起来的病理生理机制，并讨论了可考虑的不同药物和非药物治疗方式的利弊。选择性5-羟色胺再摄取抑制剂缺乏致心律失常作用，除了对抑郁有疗效外，还对心肌梗死后患者中常见的焦虑和情绪障碍等心理因素有有益影响。进一步确定抑郁对心肌梗死预后影响以及不同治疗方式地位的研究正在进行中。
