Cleophas T J
Department of Medicine, Merwede Hospital Dordrecht, Sliedrecht, The Netherlands.
Drugs Aging. 1997 Aug;11(2):111-8. doi: 10.2165/00002512-199711020-00003.
Depression and myocardial infarction (MI) are closely related. Various pathophysiological mechanisms could link depression to MI, and the different pharmacological and nonpharmacological treatment modalities that could be used have both advantages and disadvantages. Unlike tricyclic antidepressants, the selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitors (SSRIs) lack arrhythmogenic effects. In addition to their beneficial effects on depression, SSRIs have positive effects on psychological factors such as anxiety and mood disturbances that are not uncommon in patients who have had an MI. Therefore, these drugs should be preferentially considered for the treatment of depression in MI patients. Studies to further determine the impact of depression on the outcome of MI, and the place of different treatment modalities, are in progress.
抑郁症与心肌梗死（MI）密切相关。多种病理生理机制可将抑郁症与心肌梗死联系起来，而可采用的不同药物和非药物治疗方式都各有优缺点。与三环类抗抑郁药不同，选择性5-羟色胺（5-羟色胺；5-HT）再摄取抑制剂（SSRIs）没有致心律失常作用。除了对抑郁症有有益作用外，SSRIs对心肌梗死患者中并不少见的焦虑和情绪障碍等心理因素也有积极作用。因此，在治疗心肌梗死患者的抑郁症时应优先考虑使用这些药物。进一步确定抑郁症对心肌梗死预后的影响以及不同治疗方式的地位的研究正在进行中。
