Reznik M, Thiry A, Fridman V
Department of Neuropathology, Centre Hospitalier Universitaire de Liège, Belgium.
Am J Dermatopathol. 1998 Apr;20(2):203-7. doi: 10.1097/00000372-199804000-00019.
Hypertrophy and hyperplasia of pacinian corpuscles in the hand are very rare, with only 29 cases previously published. We describe two new cases in middle-aged patients whose chief complaint was progressive digital pain. Immunohistochemical and electronmicroscopic investigations indicated that the lump replicates the structure of enlarged pacinian corpuscles and should not be considered as a real tumor, nor connected to neurofibromatosis. No recurrence was observed after surgical excision. Although local trauma was encountered in 55% of the reported cases, the pathogenesis of such a lesion is still speculative.
手部帕氏小体肥大和增生非常罕见，此前仅发表过29例。我们描述了两例中年患者的新病例，其主要症状为进行性手指疼痛。免疫组织化学和电子显微镜检查表明，肿块复制了增大的帕氏小体的结构，不应被视为真正的肿瘤，也与神经纤维瘤病无关。手术切除后未观察到复发。尽管在55%的报告病例中发现了局部创伤，但这种病变的发病机制仍具有推测性。
