Fraitag S, Gherardi R, Wechsler J
Department of Anatomy and Cytopathology, Necker-Enfants Malades Hospital, Paris, France.
J Cutan Pathol. 1994 Oct;21(5):457-60. doi: 10.1111/j.1600-0560.1994.tb00289.x.
The occurrence of hyperplastic pacinian corpuscles in the hand is rare, with only 13 cases reported in the literature. We describe such a case in a 70-year-old male who had worked as a locksmith for many years. A grape-like cluster of firm, rice-sized nodules was discovered in the subcutaneous tissue of the finger following a glass-induced injury. Histopathological findings revealed pacinian corpuscles to be increased in size and number. Individual corpuscles consisted of a central nerve fiber surrounded by 35 to 60 concentric lamellae (normal controls from other specimens: 13-15 lamellae). The external corpuscular diameter ranged from 1.8 to 3.2 mm (normal controls from other specimens: 1.6 mm). Immunohistochemistry showed positive staining with Leu 7 antibody and antiglial fibrillary acidic protein in the small nerves situated in the vicinity of the pacinian corpuscles, but not in the corpuscles themselves. The lesion reported here clearly differed from both neurofibroma with occasional pacinian differentiation and the so-called pacinian neurofibroma. There was no evidence of neurofibromatosis.
手部出现增生性帕氏小体的情况较为罕见，文献中仅报道过13例。我们在此描述一例70岁男性病例，该患者曾从事多年锁匠工作。在手指因玻璃划伤后的皮下组织中发现了一串葡萄样的坚实、米粒大小的结节。组织病理学检查结果显示帕氏小体的大小和数量均增加。单个小体由一条中央神经纤维被35至60层同心板层围绕组成（其他标本的正常对照为13 - 15层板层）。小体的外径范围为从1.8至3.2毫米（其他标本的正常对照为1.6毫米）。免疫组织化学显示，在帕氏小体附近的小神经中，Leu 7抗体和抗胶质纤维酸性蛋白呈阳性染色，但小体本身无阳性染色。此处报道的病变明显不同于偶有帕氏分化的神经纤维瘤和所谓的帕氏神经纤维瘤。没有神经纤维瘤病的证据。
