Wysolmerski J J, Stewart A F
Division of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
Annu Rev Physiol. 1998;60:431-60. doi: 10.1146/annurev.physiol.60.1.431.
Parathyroid hormone-related protein (PTHrP) is the agent responsible for humoral hypercalcemia of malignancy. Its pathogenic role in this syndrome is well established and attention has focused in recent years on the elucidation of the roles played by PTHrP in normal developmental and adult physiology. This review focuses on studies of the past two years: (a) elucidation of the posttranslational processing pattern of PTHrP, the mechanisms of action of the various secretory forms of PTHrP, the role of PTHrP as an intracrine regulator of cell growth and cell death; (b) the emergence of PTHrP as a critical developmental factor in the mammary gland, epidermis, and the skeleton; and (c) the advances in understanding of the roles of PTHrP in the regulation of pancreatic islet mass, vascular smooth muscle tone and proliferation, and materno-fetal calcium transfer across the placenta.
甲状旁腺激素相关蛋白（PTHrP）是导致恶性肿瘤体液性高钙血症的介质。其在该综合征中的致病作用已得到充分证实，近年来，人们的注意力集中在阐明PTHrP在正常发育和成人生理学中所起的作用。本综述聚焦于过去两年的研究：（a）阐明PTHrP的翻译后加工模式、PTHrP各种分泌形式的作用机制、PTHrP作为细胞生长和细胞死亡的自分泌调节因子的作用；（b）PTHrP作为乳腺、表皮和骨骼中关键发育因子的出现；以及（c）在理解PTHrP在调节胰岛质量、血管平滑肌张力和增殖以及母体-胎儿钙通过胎盘转运方面的作用所取得的进展。
