Thompson E B
Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston 77555-0645, USA.
Annu Rev Physiol. 1998;60:575-600. doi: 10.1146/annurev.physiol.60.1.575.
The proto-oncogene c-myc encodes a transcription factor c-Myc, which is of great importance in controlling cell growth and vitality. The quantity of c-Myc is carefully controlled by many mechanisms, and its actions to induce and repress genes are modulated by interactions with other regulatory proteins. Understanding the kinetic and quantitative relationships that determine how and what genes c-Myc regulates is essential to understanding how Myc is involved in apoptosis. Reduction of c-myc expression and its inappropriate expression can be associated with cellular apoptosis. This review outlines the nature and regulation of the c-myc gene and of c-Myc and presents the systems and conditions in which Myc-related apoptotic events occur. Hypotheses of the mechanisms by which expression and repression of c-myc lead to apoptosis are discussed.
原癌基因c-myc编码一种转录因子c-Myc，它在控制细胞生长和活力方面具有重要意义。c-Myc的数量受到多种机制的严格控制，其诱导和抑制基因的作用通过与其他调节蛋白的相互作用来调节。了解决定c-Myc如何以及调控哪些基因的动力学和定量关系，对于理解Myc如何参与细胞凋亡至关重要。c-myc表达的降低及其异常表达可能与细胞凋亡有关。本综述概述了c-myc基因和c-Myc的性质及调控，并介绍了发生Myc相关凋亡事件的系统和条件。讨论了c-myc的表达和抑制导致细胞凋亡的机制假说。
