Pellicer Bautista F, Fernández Pérez F J, Martín Guerrero J M, Pallarés Manrique H, Hassan Asad M, Romero Castro R, Hergueta Delgado P, Herrerías Gutiérrez J M
Service of Digestive Diseases, Virgen Macarena Universitary Hospital, Sevilla, Spain.
Rev Esp Enferm Dig. 1998 Jan;90(1):23-32.
Pain in chronic pancreatitis is due to intraglandular neural affection and to pancreatic duct drainage obstruction with an increased intraductal pressure. To achieve pain relief, medical, surgical and endoscopic procedures have been developed.
To evaluate the efficacy of pancreatic duct stenting in patients with narcotic-dependent pain due to chronic pancreatitis.
From May-1994 to May-1996, ten patients (medium age: 47.5 yr) with alcoholic chronic pancreatitis were selected for this procedure. Pancreatography showed single or multiple Wirsung strictures in all cases. Papillotomy and pancreatic duct sphincterotomy were performed before stenting. Strictures were negotiated with a 7F dilating catheter over a guide wire, and intraductal calculi were removed as well. We used 7F plastic stents with variable lengths (5-10 cm), that were exchanged when the patient presented pain recurrence. Stent survival time was defined as the patient's pain-free time.
In 6 of the 10 patients stent placement was carried out successfully. A single distal Wirsung stricture was diagnosed in 3 patients while in the remaining 3 there were several strictures associated to ductal lithiasis in two of them. Mean time to achieve pain relief was 3 days and mean stent survival time was 166.5 days. There were no complications due to the procedure.
When placed through the stricture, endoscopic pancreatic stent drainage is effective in achieving pain relief. It is a safe procedure with no complications in our short series.
慢性胰腺炎疼痛是由于腺体内神经病变以及胰管引流梗阻伴管内压力升高所致。为缓解疼痛,已开展了药物、手术及内镜治疗方法。
评估胰管支架置入术对慢性胰腺炎所致依赖麻醉性镇痛药疼痛患者的疗效。
1994年5月至1996年5月,选择10例(平均年龄:47.5岁)酒精性慢性胰腺炎患者行该手术。所有病例胰管造影均显示主胰管单处或多处狭窄。在支架置入术前进行乳头切开术和胰管括约肌切开术。通过导丝用7F扩张导管通过狭窄部位,并清除管内结石。我们使用长度可变(5 - 10 cm)的7F塑料支架,患者疼痛复发时更换支架。支架存活时间定义为患者无痛时间。
10例患者中有6例成功置入支架。3例患者诊断为单一远端主胰管狭窄,其余3例中有2例存在多处狭窄并伴有导管结石。疼痛缓解的平均时间为3天,支架平均存活时间为166.5天。该手术无并发症发生。
通过狭窄部位置入内镜胰管支架引流术能有效缓解疼痛。在我们的短系列研究中,这是一种安全的手术,无并发症发生。