Leupold D, Poley J R, Meigel W N
Helv Paediatr Acta. 1976 Aug;31(2):109-15.
An infant is described with acrodermatitis enteropathica, who initially presented with severe and intractable watery diarrhea. Diagnosis was established at the age of eleven weeks. Serum-zinc concentrations were extremely low and urinary zinc excretion was diminished. Eleven days after oral zinc supplement (100 mg elemental zinc per day), the skin lesions had healed. The high therapeutic doses of zinc required for healing are suggestive that zinc malabsorption is an important pathogenetical factor of this disease.
本文描述了一名患有肠病性肢端皮炎的婴儿，其最初表现为严重且难治的水样腹泻。在11周龄时确诊。血清锌浓度极低，尿锌排泄减少。口服补锌（每天100毫克元素锌）11天后，皮肤病变愈合。愈合所需的高治疗剂量锌提示锌吸收不良是该疾病的一个重要致病因素。
