氟喹诺酮类药物用于预防小鼠卡氏肺孢子虫肺炎。

Use of fluoroquinolones for prophylaxis of murine Pneumocystis carinii pneumonia.

作者信息

Brun-Pascaud M, Fay M, Zhong M, Bauchet J, Dux-Guyot A, Pocidalo J J

机构信息

Institut National de la Santé et de la Recherche Médicale U. 13., Hôpital Claude Bernard, Paris, France.

出版信息

Antimicrob Agents Chemother. 1992 Feb;36(2):470-2. doi: 10.1128/AAC.36.2.470.

DOI:10.1128/AAC.36.2.470

PMID:1605613

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC188460/

Abstract

We compared the prophylactic activities of six fluoroquinolones against Pneumocystis carinii pneumonia in immunosuppressed rats. Pefloxacin was the only agent which was as effective as the reference drug trimethoprim-sulfamethoxazole. Clinical trials with pefloxacin in patients at risk for P. carinii pneumonia appear to be justified.

摘要

我们比较了六种氟喹诺酮类药物对免疫抑制大鼠卡氏肺孢子虫肺炎的预防作用。培氟沙星是唯一一种与参比药物甲氧苄啶-磺胺甲恶唑效果相当的药物。对有患卡氏肺孢子虫肺炎风险的患者进行培氟沙星的临床试验似乎是合理的。