Yoshino S, Kato M, Okada K
Department of Urology, Saitama Medical College, Japan.
Int J Urol. 1998 Mar;5(2):119-23. doi: 10.1111/j.1442-2042.1998.tb00258.x.
We analyzed the significance of tumor microvessel count and tumor size as prognostic factors for renal cell carcinoma (RCC).
T criteria (local invasion), M criteria (distant metastasis), macrovenous invasion, histological grade, cell type, tumor size, and tumor microvessel count were investigated as prognostic factors in 62 patients with RCC. Microvessel density was evaluated by immunohistochemical staining of the endothelial cells.
No significant correlation was found between tumor size and the other prognostic factors. Analysis of the survival rate based on tumor size revealed that patients with a small tumor tended to show a good prognosis, but no significant difference was found in the prognosis between medium-sized and large-sized tumor groups. Analysis of all patients revealed that M criteria, macrovenous invasion, cell type and microvessel count were significant factors and that in 37 patients with low-stage tumors, the only significant prognostic factor was microvessel count (P=0.003).
Tumor size cannot be readily justified as a determinant of prognosis in patients with medium- or large-sized tumors. In patients with low-stage tumors, microvessel count served as the only significant determinant for prognosis. When the patients were considered as a whole, microvessel count, M criteria, macrovenous invasion and histological grade were significant prognostic factors.
我们分析了肿瘤微血管计数和肿瘤大小作为肾细胞癌（RCC）预后因素的意义。
研究了T标准（局部侵犯）、M标准（远处转移）、大静脉侵犯、组织学分级、细胞类型、肿瘤大小和肿瘤微血管计数作为62例肾细胞癌患者的预后因素。通过内皮细胞免疫组化染色评估微血管密度。
未发现肿瘤大小与其他预后因素之间存在显著相关性。基于肿瘤大小的生存率分析显示，小肿瘤患者预后往往较好，但中、大肿瘤组之间的预后无显著差异。对所有患者的分析显示，M标准、大静脉侵犯、细胞类型和微血管计数是显著因素，在37例低分期肿瘤患者中，唯一显著的预后因素是微血管计数（P = 0.003）。
对于中、大肿瘤患者，肿瘤大小不能轻易作为预后的决定因素。在低分期肿瘤患者中，微血管计数是唯一显著的预后决定因素。当将所有患者视为一个整体时，微血管计数、M标准、大静脉侵犯和组织学分级是显著的预后因素。
