Ahluwalia J S, White D K, Morley C J
Neonatal Intensive Care Unit, Addenbrookes Hospital, Cambridge, UK.
Acta Paediatr. 1998 Mar;87(3):325-7. doi: 10.1080/08035259850157408.
The effectiveness of single prong nasal continuous positive airway pressure (CPAP) was compared with the Infant Flow Driver (IFD) in a crossover study in 20 neonates treated with > or = 30% oxygen by nasal CPAP. They were randomized to the device used at the start of the study. Each infant was studied for four consecutive 2-h periods alternating between single prong nasal CPAP and the IFD. The FiO2 from the IFD read 0.02 higher than the same setting on the ventilators used for single prong nasal CPAP. The IFD improved the mean (95% CI) of the FiO2 by 0.05 (0.02-0.08), p = 0.008. Taking into account the systematic error in the FiO2 between the devices the real mean improvement in FiO2 produced by the IFD was 0.03 (-0.005 to 0.06), p=0.09. There were no significant differences in respiratory rate, heart rate, blood pressure or comfort score of infants during periods of single nasal prong CPAP compared with periods on the IFD.
在一项交叉研究中，对20例接受经鼻持续气道正压通气（CPAP）且吸氧浓度≥30%的新生儿，比较了单鼻导管CPAP与婴儿气流驱动装置（IFD）的有效性。在研究开始时，将他们随机分配至使用的设备组。每个婴儿连续接受4个2小时的研究期，期间在单鼻导管CPAP和IFD之间交替。IFD的吸入氧分数（FiO2）读数比用于单鼻导管CPAP的呼吸机上相同设置高0.02。IFD使FiO2的平均值（95%可信区间）提高了0.05（0.02 - 0.08），p = 0.008。考虑到不同设备间FiO2的系统误差，IFD使FiO2实际平均提高0.03（-0.005至0.06），p = 0.09。与使用IFD期间相比，婴儿在单鼻导管CPAP期间的呼吸频率、心率、血压或舒适度评分无显著差异。
