Kawamoto K, Onodera H, Kondo S, Kan S, Ikeuchi D, Maetani S, Imamura M
Department of Surgery and Surgical Basic Science, Graduate School of Medicine, Kyoto University, Japan.
Oncology. 1998 May-Jun;55(3):242-8. doi: 10.1159/000011858.
Expression of insulin-like growth factor-2 (IGF-2) has been reported in tissue specimens and cell lines of human colorectal cancers. However, the effects of IGF-2 in colorectal cancer patients are not well known. In this study, IGF-2 staining was performed on tissue samples from 92 patients with colorectal cancer, and the relationship of IGF-2 staining to clinicopathological variables, proliferating cell nuclear antigen (PCNA) staining and patient survival was analyzed. IGF-2 staining was correlated with tumor progression, PCNA staining and patient survival. Our results suggest that IGF-2 plays an important role in tumor progression and that IGF-2 staining is useful as a prognostic factor in colorectal cancer patients.
胰岛素样生长因子-2（IGF-2）已在人类结直肠癌的组织标本和细胞系中被报道。然而，IGF-2在结直肠癌患者中的作用尚不清楚。在本研究中，对92例结直肠癌患者的组织样本进行了IGF-2染色，并分析了IGF-2染色与临床病理变量、增殖细胞核抗原（PCNA）染色及患者生存的关系。IGF-2染色与肿瘤进展、PCNA染色及患者生存相关。我们的结果表明，IGF-2在肿瘤进展中起重要作用，且IGF-2染色可作为结直肠癌患者的预后因素。
