Gligorijević Nikola, Dobrijević Zorana, Šunderić Miloš, Robajac Dragana, Četić Danilo, Penezić Ana, Miljuš Goran, Nedić Olgica
Institute for the Application of Nuclear Energy, Department for Metabolism, University of Belgrade, Banatska 31b, 11080 Belgrade, Serbia.
Life (Basel). 2022 Aug 20;12(8):1274. doi: 10.3390/life12081274.
Insulin-like growth factors (IGFs) are peptides which exert mitogenic, endocrine and cytokine activities. Together with their receptors, binding proteins and associated molecules, they participate in numerous pathophysiological processes, including cancer development. Colorectal cancer (CRC) is a disease with high incidence and mortality rates worldwide, whose etiology usually represents a combination of the environmental and genetic factors. IGFs are most often increased in CRC, enabling excessive autocrine/paracrine stimulation of the cell growth. Overexpression or increased activation/accessibility of IGF receptors is a coinciding step which transmits IGF-related signals. A number of molecules and biochemical mechanisms exert modulatory effects shaping the final outcome of the IGF-stimulated processes, frequently leading to neoplastic transformation in the case of irreparable disbalance. The IGF system and related molecules and pathways which participate in the development of CRC are the focus of this review.
胰岛素样生长因子（IGFs）是一类具有促有丝分裂、内分泌和细胞因子活性的肽。它们与其受体、结合蛋白及相关分子一起，参与众多病理生理过程，包括癌症的发生发展。结直肠癌（CRC）是一种在全球范围内发病率和死亡率都很高的疾病，其病因通常是环境因素和遗传因素共同作用的结果。IGFs在结直肠癌中通常会升高，从而导致细胞生长过度的自分泌/旁分泌刺激。IGF受体的过表达或激活/可及性增加是传递IGF相关信号的一个同步步骤。许多分子和生化机制发挥调节作用，塑造IGF刺激过程的最终结果，在无法修复失调的情况下常常导致肿瘤转化。参与结直肠癌发生发展的IGF系统及相关分子和途径是本综述的重点。
