G蛋白信号传导：微调信号动力学
G-protein signaling: fine-tuning signaling kinetics.
作者信息
Zerangue N, Jan L Y
机构信息
Howard Hughes Medical Institute, Department of Physiology, University of California San Francisco, California 94143, USA.
出版信息
Curr Biol. 1998 Apr 23;8(9):R313-6. doi: 10.1016/s0960-9822(98)70196-4.
PMID:9560334
Abstract
Mammalian 'regulators of G protein signaling' (RGS proteins) help shut off G-protein-mediated signaling by GTPase activation. But new evidence shows that RGS proteins can also speed up the activation of signaling. The combined effect is a change in signaling kinetics without a decrease in signaling intensity.
摘要
哺乳动物的“G蛋白信号调节因子”（RGS蛋白）通过激活GTP酶来帮助关闭G蛋白介导的信号传导。但新证据表明，RGS蛋白也能加速信号传导的激活。综合效应是信号动力学发生变化，而信号强度不降低。
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