Guerini D
Institute of Biochemistry, Biochemie III, (ETH)-Zentrum, Universitätstrasse 16, CH-8092 Zürich, Switzerland.
Cell Tissue Res. 1998 May;292(2):191-7. doi: 10.1007/s004410051050.
The plasma membrane calcium ATPase (PMCA) or Ca2+ pump transports Ca2+ ions out of the cells, by using the energy stored in ATP. It is essential in the control of Ca2+ concentration in the cytosol. The plasma membrane Ca2+ pump has been found in all mammalian cells and is encoded by four independent genes. The number of possible isoforms is further increased by alternative splicing at two independent sites; transcripts for more than 20 isoforms have been detected. The PMCA isoforms, in particular some of their alternatively spliced isoforms, have been shown to bind calmodulin with different affinity. The activity of these alternatively spliced pumps is possibly differently regulated by kinase-mediated phosphorylation. A short summary of recent work on the properties of the PMCA isoforms is presented here.
质膜钙ATP酶（PMCA）或钙泵利用ATP中储存的能量将钙离子转运出细胞。它对于控制胞质溶胶中的钙离子浓度至关重要。质膜钙泵存在于所有哺乳动物细胞中，由四个独立的基因编码。通过在两个独立位点的可变剪接，可能的同工型数量进一步增加；已检测到20多种同工型的转录本。PMCA同工型，特别是它们的一些可变剪接同工型，已被证明以不同的亲和力结合钙调蛋白。这些可变剪接泵的活性可能受到激酶介导的磷酸化的不同调节。本文简要总结了关于PMCA同工型特性的近期研究工作。
