Wasi P
Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Southeast Asian J Trop Med Public Health. 1997;28 Suppl 2:19-24.
Human genome research which tries to map and sequence all the 3 billion nucleotides in the entire DNA is progressing rapidly. Completion of the human genome sequencing is expected before the year 2005. Human genes, totalling 50,000-100,000, will be identified, allowing the complete set of proteins--'the proteome' to be known. This together with genomic research in other species will lead to complete understanding of life at the molecular level and also its evolutionary history of 3,500 million years. Genomics will bring about a revolution in biology and health, because it is equivalent to having a 'Biological Periodic Table' which is a foundation for understanding life, health, disease and for deriving of new tools for diagnosis, treatment, prognosis and prevention. Human genomics will give rise to Predictive--Preventive Medicine and Precision Medicine. It will have profound social implications. Preparation for the future is needed for societies to cope with and make proper use of the tremendous changes to be brought about by genomics.
致力于绘制和测序整个DNA中所有30亿个核苷酸的人类基因组研究正在迅速推进。预计在2005年前完成人类基因组测序。届时将识别出总数达5万至10万个的人类基因,从而使整套蛋白质——“蛋白质组”为人所知。这与对其他物种的基因组研究一起,将带来对分子水平生命的全面理解以及对其35亿年进化史的了解。基因组学将引发生物学和健康领域的一场革命,因为它相当于拥有一张“生物周期表”,这是理解生命、健康、疾病以及开发诊断、治疗、预后和预防新工具的基础。人类基因组学将催生预测性——预防性医学和精准医学。它将产生深远的社会影响。社会需要为未来做好准备,以应对并妥善利用基因组学带来的巨大变化。