Chicurel M E, Chen C S, Ingber D E
Department of Surgery, Children's Hospital, Boston, MA, USA.
Curr Opin Cell Biol. 1998 Apr;10(2):232-9. doi: 10.1016/s0955-0674(98)80145-2.
Mechanical tension generated within the cytoskeleton of living cells is emerging as a critical regulator of biological function in diverse situations ranging from the control of chromosome movement to the morphogenesis of the vertebrate brain. In this article, we review recent advances that have been made in terms of understanding how cells generate, transmit and sense mechanical tension, as well as how they use these forces to control their shape and behavior. An integrated view of cell regulation that incorporates mechanics and structure as well as chemistry is beginning to emerge.
活细胞细胞骨架内产生的机械张力正逐渐成为多种情况下生物功能的关键调节因子，这些情况涵盖从染色体运动的控制到脊椎动物大脑的形态发生。在本文中，我们回顾了在理解细胞如何产生、传递和感知机械张力，以及它们如何利用这些力来控制自身形状和行为方面所取得的最新进展。一种将力学、结构以及化学整合在一起的细胞调节综合观点正开始形成。
