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冠状动脉支架置入术后早期出现的酷似败血症的噻氯匹定诱导的中性粒细胞减少症。

Ticlopidine-induced neutropenia mimicking sepsis early after intracoronary stent placement.

作者信息

Ochoa A B, Wolfe M, Lewis P, Lenihan D J

机构信息

Wright-Patterson Medical Center, Department of Internal Medicine, Wright-Patterson Air Force Base, OH 45433, USA.

出版信息

Clin Cardiol. 1998 Apr;21(4):304-7. doi: 10.1002/clc.4960210417.

DOI:10.1002/clc.4960210417
PMID:9562945
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6655651/
Abstract

We report a case of ticlopidine-induced profound neutropenia early in the course of therapy, which was manifest as a febrile systemic illness mimicking sepsis. This clinical presentation was potentially indicative of a contaminated intracoronary stent. The patient's signs and symptoms of illness promptly resolved with removal of ticlopidine, and no infection was documented. Review of indications for ticlopidine use, potential adverse effects, and monitoring recommendations are discussed.

摘要

我们报告一例在治疗早期由噻氯匹定引起的严重中性粒细胞减少症，表现为类似败血症的发热性全身疾病。这种临床表现可能提示冠状动脉内支架受到污染。停用噻氯匹定后，患者的疾病体征和症状迅速缓解，且未记录到感染情况。本文讨论了噻氯匹定的使用指征、潜在不良反应及监测建议。

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Ticlopidine-induced neutropenia mimicking sepsis early after intracoronary stent placement.冠状动脉支架置入术后早期出现的酷似败血症的噻氯匹定诱导的中性粒细胞减少症。
Clin Cardiol. 1998 Apr;21(4):304-7. doi: 10.1002/clc.4960210417.
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引用本文的文献

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Hematologic dyscrasia associated with ticlopidine therapy: evidence for causality.噻氯匹定治疗相关的血液系统异常：因果关系的证据。
CMAJ. 2000 Nov 28;163(11):1441-8.

本文引用的文献

1
Coronary artery stents. American College of Cardiology.冠状动脉支架。美国心脏病学会。
J Am Coll Cardiol. 1996 Sep;28(3):782-94.
2
A randomized comparison of antiplatelet and anticoagulant therapy after the placement of coronary-artery stents.冠状动脉支架置入术后抗血小板治疗与抗凝治疗的随机对照比较。
N Engl J Med. 1996 Apr 25;334(17):1084-9. doi: 10.1056/NEJM199604253341702.
3
Reduction in thrombotic events with heparin-coated Palmaz-Schatz stents in normal porcine coronary arteries.肝素涂层Palmaz-Schatz支架减少正常猪冠状动脉血栓形成事件。
Circulation. 1996 Feb 1;93(3):423-30. doi: 10.1161/01.cir.93.3.423.
4
Heparin-coated Palmaz-Schatz stents in human coronary arteries. Early outcome of the Benestent-II Pilot Study.
Circulation. 1996 Feb 1;93(3):412-22. doi: 10.1161/01.cir.93.3.412.
5
A randomized comparison of combined ticlopidine and aspirin therapy versus aspirin therapy alone after successful intravascular ultrasound-guided stent implantation.
Circulation. 1996 Jan 15;93(2):215-22. doi: 10.1161/01.cir.93.2.215.
6
Thrombotic thrombocytopenic purpura associated with ticlopidine.
Ann Pharmacother. 1993 Sep;27(9):1060-1. doi: 10.1177/106002809302700910.
7
Intracoronary stenting without anticoagulation accomplished with intravascular ultrasound guidance.在血管内超声引导下进行无抗凝治疗的冠状动脉内支架置入术。
Circulation. 1995 Mar 15;91(6):1676-88. doi: 10.1161/01.cir.91.6.1676.
8
Fatal neutropenia and thrombocytopenia associated with ticlopidine.与噻氯匹定相关的致命性中性粒细胞减少和血小板减少。
Ann Pharmacother. 1994 Nov;28(11):1236-8. doi: 10.1177/106002809402801103.
9
Ticlopidine and fatal aplastic anemia in an elderly woman.
Ann Pharmacother. 1994 Oct;28(10):1169-71. doi: 10.1177/106002809402801007.
10
Agranulocytosis caused by ticlopidine and its mechanism.噻氯匹定引起的粒细胞缺乏症及其机制。
Am J Hematol. 1991 Aug;37(4):239-42. doi: 10.1002/ajh.2830370405.