通过气相色谱-质谱联用技术鉴定新型降血脂药物2-(4'(对氯苯甲酰基)苯氧基)-2-甲基丙酸异丙酯（普罗考芬）在人体中的主要代谢产物。 - Suppr | 超能文献

Identification of a major metabolite of the new hypolipidaemic agent, isopropyl 2-(4'(p-chlorobenzoyl) phenoxy)-2-methylpropionate (procetofene) in humans by gas chromatography-mass spectrometry.

作者信息

Elsom L F, Hawkins D R, Chasseaud L F

出版信息

J Chromatogr. 1976 Aug 4;123(2):463-7. doi: 10.1016/s0021-9673(00)82222-0.

DOI:10.1016/s0021-9673(00)82222-0

Abstract

摘要

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1

Identification of a major metabolite of the new hypolipidaemic agent, isopropyl 2-(4'(p-chlorobenzoyl) phenoxy)-2-methylpropionate (procetofene) in humans by gas chromatography-mass spectrometry.通过气相色谱-质谱联用技术鉴定新型降血脂药物2-(4'(对氯苯甲酰基)苯氧基)-2-甲基丙酸异丙酯（普罗考芬）在人体中的主要代谢产物。

J Chromatogr. 1976 Aug 4;123(2):463-7. doi: 10.1016/s0021-9673(00)82222-0.

2

Metabolism of SU-13437--a new hypolipidemic drug in man.新型降血脂药物SU - 13437在人体中的代谢

Clin Pharmacol Ther. 1970 Jan-Feb;11(1):97-105. doi: 10.1002/cpt197011197.

3

Gas--liquid chromatographic determination of procetofenic acid in human plasma and urine.气相色谱法测定人血浆和尿液中普罗昔康酸的含量。

J Chromatogr. 1978 Jan 1;145(1):160-4. doi: 10.1016/s0378-4347(00)81681-3.

4

Determination of a new hypolipidemic agent, 2-(trans-4-isobutylcyclohexyl)-2-oxoethyl benzenesulphonate, and its metabolite by high-performance liquid chromatography and gas chromatography-mass fragmentography in human biological materials.用高效液相色谱法和气相色谱-质谱碎片分析法测定人生物材料中一种新型降血脂药——2-(反式-4-异丁基环己基)-2-氧代乙基苯磺酸盐及其代谢物。

J Chromatogr. 1988 Dec 9;433:282-7. doi: 10.1016/s0378-4347(00)80609-x.

5

Antilipidemic drugs. Part 4: The metabolic fate of the hypolipidemic agent isopropyl-[4'-(p-chlorobenzoyl)-2-phenoxy-2-methyl]-protionate (LF 178) in rats, dog and man.降血脂药物。第4部分：降血脂剂异丙基-[4'-(对氯苯甲酰基)-2-苯氧基-2-甲基]-丙酸酯（LF 178）在大鼠、狗和人体内的代谢命运。

Arzneimittelforschung. 1976;26(5):896-901.

6

Antilipidemic drugs. Part 3: On the synthesis of 14C-radiolabelled isopropyl-[4'-chlorobenzoyl)-2-phenoxy-2-methyl]-propionate (LF-178).抗血脂药。第3部分：14C放射性标记的异丙基-[（4'-氯苯甲酰基）-2-苯氧基-2-甲基] -丙酸酯（LF-178）的合成

Arzneimittelforschung. 1976;26(5):894-5.

7

Antilipidemic drugs. Part 2: Experimental study of a new potent hypolipidemic drug, isopropyl-[4'-(p-chlorobenzoyl)-2-phenoxy-2-methyl]-propionate (LF178).抗血脂药物。第2部分：一种新型强效抗血脂药物异丙基-[4'-(对氯苯甲酰基)-2-苯氧基-2-甲基]-丙酸酯（LF178）的实验研究。

Arzneimittelforschung. 1976;26(5):889-94.

8

Atilipidemic drugs. Part 5: Evaluation of the hypolipidemic effect of LF 178 in 191 patients affected by the atherogenic form of endogenous hyperlipoproteinemia (types IIa, IIb and IV).抗脂药物。第5部分：LF 178对191例患致动脉粥样硬化型内源性高脂蛋白血症（IIa型、IIb型和IV型）患者的降血脂作用评估。

Arzneimittelforschung. 1976;26(5):901-6.

9

Gas chromatographic determination of gemfibrozil and its metabolites in plasma and urine.气相色谱法测定血浆和尿液中吉非贝齐及其代谢物

J Chromatogr. 1984 Apr 13;307(1):210-5. doi: 10.1016/s0378-4347(00)84090-6.

10

Effects of a salt of cholestyramine and 2-[4-(p-chlorobenzoyl)phenoxy]2-methyl propionic acid (alpha-1081) on biliary lipid secretion in rats.消胆胺与2-[4-(对氯苯甲酰基)苯氧基]-2-甲基丙酸（α-1081）的盐对大鼠胆汁脂质分泌的影响。

Br J Pharmacol. 1981 Nov;74(3):611-7. doi: 10.1111/j.1476-5381.1981.tb10471.x.

引用本文的文献

1

Distribution of fenofibric acid in lipoprotein fractions of patients.非诺贝特酸在患者脂蛋白组分中的分布。

Eur J Drug Metab Pharmacokinet. 1998 Apr-Jun;23(2):287-94. doi: 10.1007/BF03189353.

2

The influence of renal insufficiency and haemodialysis on the kinetics of ciprofibrate.肾功能不全和血液透析对环丙贝特动力学的影响。

Br J Clin Pharmacol. 1989 Dec;28(6):675-81. doi: 10.1111/j.1365-2125.1989.tb03560.x.

3

Urinary glucuronide excretion of fenofibric and clofibric acid glucuronides in man. Is it polymorphic?

Eur J Clin Pharmacol. 1991;41(2):153-9. doi: 10.1007/BF00265909.