Houinato D, Verdier M, Preux P M, Josse R, Letenneur L, Ayed Z, Avodé G, Massit B, Boutros-Toni F, Denis F, Zohoun T, Salamon R, Dumas M
Institute of Neuroepidemiology and Tropical Neurology, School of Medicine, Limoges, France.
Int J Epidemiol. 1998 Feb;27(1):146-52. doi: 10.1093/ije/27.1.146.
Few data exist concerning familial human T-cell leukaemia virus type I (HTLV-I) carrier states and transmission in African countries. Two previous surveys performed in Benin in 1989 and 1990 using a three-level cluster sampling method allowed us to identify HTLV-I positive subjects. The evolution of HTLV-I within the families of these subjects is described over a 4-year period, 1991-1995.
Since 1991, 37 HTLV-I seropositive subjects, six subjects with indeterminate Western-Blot pattern, and their relatives have been followed up once a year clinically and biologically.
Twenty-three mothers in the study group gave birth to 27 children between 1991 and 1995. Among the 13 infants born to the 12 seropositive mothers, two seroconverted before their second birthday. One adult woman whose husband was seropositive developed seropositivity 4 years after marriage. In March 1992, a family case-control study (proband study) was conducted. A seroprevalence of 27.5% was found among 138 relatives of 32 infected subjects and 1.4% among 142 relatives of 32 control subjects.
There is clearly an intrafamilial clustering of HTLV-I in Benin. The annual incidence density of HTLV-I in this cohort is estimated at 6 per thousand.
在非洲国家，关于人类T细胞白血病病毒I型（HTLV-I）携带者状态及传播的资料很少。1989年和1990年在贝宁进行的两项先前调查采用三级整群抽样方法，使我们能够识别出HTLV-I阳性个体。本文描述了1991年至1995年这4年间这些个体家庭中HTLV-I的演变情况。
自1991年以来，对37名HTLV-I血清学阳性个体、6名免疫印迹结果不确定的个体及其亲属每年进行一次临床和生物学随访。
研究组中的23名母亲在1991年至1995年间生育了27名儿童。在12名血清学阳性母亲所生的13名婴儿中，有2名在2岁生日前发生了血清转化。一名成年女性，其丈夫血清学阳性，在婚后4年出现血清学阳性。1992年3月，进行了一项家庭病例对照研究（先证者研究）。在32名受感染个体的138名亲属中，血清阳性率为27.5%；在32名对照个体的142名亲属中，血清阳性率为
