Srisomboon J, Pongpisuttinun S
Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Thailand.
J Obstet Gynaecol Res. 1998 Feb;24(1):1-5. doi: 10.1111/j.1447-0756.1998.tb00044.x.
To study the complications and compare the success rate and abortion time between the live and the dead fetuses in second-trimester pregnancy termination with intracervicovaginal misoprostol.
A prospective comparative study.
A total of 89 pregnant women between 14 and 28 weeks of gestation with obstetric, medical, or genetic reasons for termination of pregnancy were recruited to receive 200 micrograms misoprostol inserted intracervicovaginally every 12 hours.
The rates of successful abortions within 12, 24 and 48 hours in live fetuses were 15.1%, 54.7% and 92.5%, respectively, while in dead fetuses were 50.0%, 83.3% and 97.2%, respectively. The success rates within 12 and 24 hours in live-fetus group were significantly lower than those of the dead-fetus group 9p = 0.0009 and p = 0.01, respectively). The mean abortion time of the live-fetus group (27.1 hours) was significantly more than that of the dead-fetus group (15 hours, p = 0.001). No serious complications occurred in terms of hemorrhage, febrile morbidity diarrhea, nausea and vomiting.
Intracervicovaginal misoprostol is an effective and safe method for second-trimester pregnancy termination. The success rate is higher and the abortion time is less in dead-fetus pregnancy than those in the live-fetus pregnancy.
研究米索前列醇宫颈阴道内给药用于孕中期终止妊娠时的并发症，并比较活胎与死胎的成功率及流产时间。
前瞻性对照研究。
共纳入89例妊娠14至28周因产科、内科或遗传因素需终止妊娠的孕妇，每12小时宫颈阴道内塞入200微克米索前列醇。
活胎组12、24及48小时内的流产成功率分别为15.1%、54.7%和92.5%，死胎组分别为50.0%、83.3%和97.2%。活胎组12小时和24小时内的成功率显著低于死胎组（分别为p = 0.0009和p = 0.01）。活胎组的平均流产时间（27.1小时）显著长于死胎组（15小时，p = 0.001）。在出血、发热性疾病、腹泻、恶心和呕吐方面未发生严重并发症。
米索前列醇宫颈阴道内给药是孕中期终止妊娠的一种有效且安全的方法。死胎妊娠的成功率高于活胎妊娠，且流产时间更短。
