Sakura M, Nakabayashi M, Takeda Y, Sato K
Department of Obstetrics and Gynaecology, Tokyo Women's Medical College, Japan.
J Obstet Gynaecol Res. 1998 Feb;24(1):73-6. doi: 10.1111/j.1447-0756.1998.tb00055.x.
To examine early midtrimester amniotic fluid for its significance in pregnancy outcomes, especially with connection to the pathogenesis of preeclampsia.
A prospective, nested, case-control study was conducted. Fetal fibronectin in early midtrimester (16-20 weeks gestation) amniotic fluid was measured by EIA method. Results were compared by their pregnancy outcomes.
Amniotic fluid levels of fetal fibronectin were significantly higher in the group subsequently developing severe preeclampsia (106.8 +/- 13.2 micrograms/ml, mean +/- SD, n = 12) compared with matched controls (66.7 +/- 7.1 micrograms/ml, n = 12) (p < 0.05).
High levels of fetal fibronectin were found in the amniotic fluid of women subsequently developing severe preeclampsia before any symptom appear. Involvement of extracellular injury or cellular hyperactivity in the midtrimester placental site with the onset of preeclampsia is suggested.
检测孕中期早期羊水对妊娠结局的意义，尤其是与子痫前期发病机制的关系。
进行一项前瞻性、巢式病例对照研究。采用酶免疫分析法测定孕中期早期（妊娠16 - 20周）羊水中的胎儿纤连蛋白。根据妊娠结局比较结果。
与匹配对照组（66.7±7.1微克/毫升，n = 12）相比，随后发生重度子痫前期的组（106.8±13.2微克/毫升，均值±标准差，n = 12）羊水中胎儿纤连蛋白水平显著更高（p < 0.05）。
在随后发生重度子痫前期的女性羊水中，在任何症状出现之前就发现了高水平的胎儿纤连蛋白。提示孕中期胎盘部位的细胞外损伤或细胞活性亢进与子痫前期的发病有关。
