Malone R P, Bennett D S, Luebbert J F, Rowan A B, Biesecker K A, Blaney B L, Delaney M A
Department of Psychiatry, Eastern Pennsylvania Psychiatric Institute, Philadelphia 19129, USA.
Psychopharmacol Bull. 1998;34(1):41-5.
This preliminary study investigated whether the aggression subtypes derived from the Aggression Questionnaire (AQ) are related to treatment response. The subjects were 28 aggressive conduct-disordered children (25 males, 3 females), ranging in age from 9.8 to 17.0 years (mean age = 12.69 years), who participated in a double-blind, placebo-controlled study of lithium as a treatment for reducing aggression. We used the Predatory-Affective Index of the AQ to classify subjects into "predatory" (planned) or "affective" (explosive) subtypes of aggression and then related this classification to treatment response. This index did not differentiate placebo baseline responders from nonresponders. However, the Index did significantly differentiate responders and nonresponders during the experimental treatment period, regardless of whether they received lithium or placebo. Treatment response was associated with a more affective and less predatory subtype of aggression. To the best of our knowledge, this is the first study in children to show an association between the aggression subtype and treatment response.
这项初步研究调查了源自攻击问卷（AQ）的攻击亚型是否与治疗反应相关。研究对象为28名有攻击行为的品行障碍儿童（25名男性，3名女性），年龄在9.8岁至17.0岁之间（平均年龄 = 12.69岁），他们参与了一项关于锂盐治疗减少攻击行为的双盲、安慰剂对照研究。我们使用AQ的掠夺性 - 情感指数将研究对象分为“掠夺性”（有计划的）或“情感性”（爆发性的）攻击亚型，然后将这种分类与治疗反应联系起来。该指数在安慰剂基线期未能区分反应者和无反应者。然而，在实验治疗期，无论他们接受的是锂盐还是安慰剂，该指数确实显著区分了反应者和无反应者。治疗反应与更具情感性和较少掠夺性的攻击亚型相关。据我们所知，这是第一项在儿童中显示攻击亚型与治疗反应之间存在关联的研究。
