重组牛生长激素治疗绵羊妊娠毒血症的评估

Evaluation of recombinant bovine somatotropin in the treatment of ovine pregnancy toxaemia.

作者信息

Scott P R, Sargison N D, Penny C D

机构信息

Department of Veterinary Clinical Studies, Scotland, UK.

出版信息

Vet J. 1998 Mar;155(2):197-9. doi: 10.1016/s1090-0233(98)80019-1.

DOI:10.1016/s1090-0233(98)80019-1

PMID:9564274

Abstract

Forty multigravid ewes with naturally-occurring ovine pregnancy toxaemia were treated with a concentrated oral dextrose and electrolyte solution administered three times daily an oral and a single subcutaneous injection of either a slow release formulation of 160mg recombinant bovine somatotropin (n = 17) or placebo injection (n = 23). A higher recovery rate was achieved in ewes treated with 160mg recombinant bovine somatotropin compared with controls (58.8 versus 34.8%, respectively), and more lambs were born alive and survived to 24th from treated ewes (15 of 46 lambs; 32.6%) compared with control ewes (12 of 62 lambs; 19.4%) but the treatment effects were not significantly different from the control group (P > 0.05).

摘要

40只自然发生绵羊妊娠毒血症的经产母羊，每天三次口服浓缩葡萄糖和电解质溶液，并分别口服和皮下注射一次160mg重组牛生长激素缓释制剂（n = 17）或安慰剂注射（n = 23）。与对照组相比，用160mg重组牛生长激素治疗的母羊恢复率更高（分别为58.8%和34.8%），与对照母羊（62只羔羊中的12只；19.4%）相比，治疗母羊出生时存活并存活至第24天的羔羊更多（46只羔羊中的15只；32.6%），但治疗效果与对照组无显著差异（P>0.05）。