全氟碳乳液的稳定性及其与血清的相容性。

Stability of perfluorocarbon emulsions and their compatibility with blood serum.

作者信息

Kuznetsova I N

机构信息

Laboratory of Blood Substitutes, Russian Research Institute of Hematology and Transfusiology, St. Petersburg, Russia.

出版信息

Artif Cells Blood Substit Immobil Biotechnol. 1998 Mar;26(2):181-9. doi: 10.3109/10731199809119776.

DOI:10.3109/10731199809119776

PMID:9564436

Abstract

There is not enough to study of the perfluorocarbon (PFC) emulsions particle size only for judgment the question about their stability and quality. It is essential to evaluate also the structure alteration of PFC emulsions and their compatibility with the blood serum. It was shown that stability of PFC emulsion of the same composition depend on the mode of their preparing. The particle size of frozen PFC emulsions as a rule does not change at storage and their compatibility with blood serum can remain unchanged. However, the integrity of particle structure of PFC emulsions may be destroyed at unfreezing. The average diameter of PFC emulsion particles may remain unchanged at storage, but the compatibility with blood serum may become worse.

摘要

仅通过研究全氟碳（PFC）乳剂的粒径，不足以判断其稳定性和质量问题。评估PFC乳剂的结构变化及其与血清的相容性也至关重要。结果表明，相同组成的PFC乳剂的稳定性取决于其制备方式。冷冻的PFC乳剂的粒径通常在储存时不会改变，并且它们与血清的相容性可能保持不变。然而，PFC乳剂颗粒结构的完整性在解冻时可能会被破坏。PFC乳剂颗粒的平均直径在储存时可能保持不变，但与血清的相容性可能会变差。