右侧单侧电休克治疗期间低剂量、中等剂量和高剂量刺激下发作期脑电图规律性的变化
Variation of ictal electroencephalographic regularity with low-, moderate-, and high-dose stimuli during right unilateral electroconvulsive therapy.
作者信息
McCall W V, Sparks W, Jane J, Rosenquist P B, Colenda C C, Reboussin D M
机构信息
Department of Psychiatry, Bowman Gray School of Medicine, Winston-Salem, North Carolina 27157, USA.
出版信息
Biol Psychiatry. 1998 Apr 15;43(8):608-11. doi: 10.1016/s0006-3223(97)10022-1.
BACKGROUND
Previous work has demonstrated changes in electroencephalographic (EEG) ictal morphology during electroconvulsive therapy (ECT) as stimulus intensity is increased from barely suprathreshold to moderately suprathreshold. Our study reports on the reactivity of seizure regularity ratings in 11 subjects receiving right unilateral (RUL) ECT as the stimulus is varied over a wider range of intensities from low to medium, then high dose.
METHODS
The stimulus intensity of all 11 subjects was first increased from barely suprathreshold to moderately suprathreshold, and then randomized to either stay at a moderately suprathreshold dose or increase to a high dose. The regularity of the EEG ictal discharge was visually measured on a seven-point scale.
RESULTS
We found that seizure regularity increases as the stimulus intensity moves from the barely suprathreshold to the moderately suprathreshold dosage, but did not increase further when the stimulus increased to a high dose.
CONCLUSIONS
These results suggest that EEG regularity is unlikely to distinguish moderately suprathreshold from markedly suprathreshold stimuli during RUL ECT.
背景
先前的研究表明，在电休克治疗（ECT）期间，随着刺激强度从刚刚超过阈值增加到中度超过阈值，脑电图（EEG）发作期形态会发生变化。我们的研究报告了11名接受右侧单侧（RUL）ECT治疗的受试者在刺激强度从低到中再到高剂量的更广泛范围内变化时，癫痫发作规律性评分的反应性。
方法
11名受试者的刺激强度首先从刚刚超过阈值增加到中度超过阈值，然后随机分为维持在中度超过阈值剂量或增加到高剂量。通过七点量表直观测量EEG发作期放电的规律性。
结果
我们发现，随着刺激强度从刚刚超过阈值增加到中度超过阈值剂量，癫痫发作规律性增加，但当刺激增加到高剂量时，癫痫发作规律性不再进一步增加。
结论
这些结果表明，在RUL ECT期间，EEG规律性不太可能区分中度超过阈值和明显超过阈值的刺激。
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