双相情感障碍心境正常患者血小板中及锂治疗大鼠脑中咪唑啉受体的密度
Density of imidazoline receptors in platelets of euthymic patients with bipolar affective disorder and in brains of lithium-treated rats.
作者信息
García-Sevilla J A, Escribá P V, Ozaita A, Walzer C, Guimón J
机构信息
Department of Psychiatry, Medical School, University of Geneva, Switzerland.
出版信息
Biol Psychiatry. 1998 Apr 15;43(8):616-8. doi: 10.1016/s0006-3223(97)00398-3.
BACKGROUND
Platelet imidazoline receptors have been shown to be up-regulated in patients with unipolar major depression. This study examines the status of imidazoline receptor proteins in platelets of euthymic bipolar patients and in brains of lithium-treated rats.
METHODS
Platelets were collected from 12 bipolar patients (lithium-treated or drug-free) and brains from chronic lithium-treated rats. Imidazoline receptors were quantitated by immunoblotting, using a specific antiserum, and/or radioligand binding.
RESULTS
No changes in platelet imidazoline receptors (35-kDa and 45-kDa proteins) were found. Lithium treatment did not alter brain imidazoline receptors (29/30-kDa, 45-kDa, and 66-kDa proteins or density/affinity of [3H]-idazoxan binding sites).
CONCLUSIONS
Imidazoline receptor proteins are not altered in platelets of euthymic patients with bipolar affective disorder.
背景
血小板咪唑啉受体已被证明在单相重度抑郁症患者中上调。本研究检测了双相情感障碍缓解期患者血小板和锂盐治疗大鼠脑中咪唑啉受体蛋白的状态。
方法
采集12例双相情感障碍患者（锂盐治疗或未用药）的血小板以及慢性锂盐治疗大鼠的脑。使用特异性抗血清通过免疫印迹和/或放射性配体结合对咪唑啉受体进行定量。
结果
未发现血小板咪唑啉受体（35 kDa和45 kDa蛋白）有变化。锂盐治疗未改变脑咪唑啉受体（29/30 kDa、45 kDa和66 kDa蛋白或[3H] - 伊达唑胺结合位点的密度/亲和力）。
结论
双相情感障碍缓解期患者的血小板中咪唑啉受体蛋白未改变。
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