Dorman S E, Gill V J, Gallin J I, Holland S M
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-1886, USA.
Clin Infect Dis. 1998 Apr;26(4):889-94. doi: 10.1086/513928.
Burkholderia species, notably Burkholderia cepacia and Burkholderia gladioli, are important pathogens in patients with chronic granulomatous disease (CGD). Burkholderia pseudomallei, the causative agent of melioidosis, is endemic in Southeast Asia and northern Australia but is a rare pathogen in other parts of the world. We describe the occurrence of B. pseudomallei infection in a Puerto Rican patient with CGD. This is one of only a small number of documented cases of melioidosis autochthonous to the Americas and is the first reported case of B. pseudomallei infection in a CGD patient from the Americas. We conclude that B. pseudomallei, like B. cepacia and B. gladioli, should be considered a potential pathogen in patients with CGD and that melioidosis should be considered in the differential diagnosis for ill residents of or travelers to Puerto Rico.
伯克霍尔德菌属，尤其是洋葱伯克霍尔德菌和唐菖蒲伯克霍尔德菌，是慢性肉芽肿病（CGD）患者的重要病原体。类鼻疽杆菌是类鼻疽病的病原体，在东南亚和澳大利亚北部为地方病，但在世界其他地区是罕见病原体。我们描述了一名患有CGD的波多黎各患者感染类鼻疽杆菌的情况。这是美洲仅有的少数几例有记录的本土类鼻疽病病例之一，也是美洲首例报告的CGD患者感染类鼻疽杆菌的病例。我们得出结论，类鼻疽杆菌与洋葱伯克霍尔德菌和唐菖蒲伯克霍尔德菌一样，应被视为CGD患者的潜在病原体，对于波多黎各的患病居民或旅行者，在鉴别诊断中应考虑类鼻疽病。
